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Podophyllotoxin: History, Recent Advances and Future Prospects

dc.contributor.authorZinnia Shah
dc.contributor.authorUmar Farooq Gohar
dc.contributor.authorIffat Jamshed
dc.contributor.authorAamir Mushtaq
dc.contributor.authorHamid Mukhtar
dc.contributor.authorMuhammad Zia-UI-Haq
dc.contributor.authorSebastian Ionut Toma
dc.contributor.authorRosana Manea
dc.contributor.authorMarius Moga
dc.contributor.authorBianca Popovici
dc.contributor.otherInstitute of Industrial Biotechnology (IIB), Government College University, Lahore 54000, Pakistan
dc.contributor.otherInstitute of Industrial Biotechnology (IIB), Government College University, Lahore 54000, Pakistan
dc.contributor.otherInstitute of Industrial Biotechnology (IIB), Government College University, Lahore 54000, Pakistan
dc.contributor.otherGulab Devi Institute of Pharmacy, Gulab Devi Educational Complex, Lahore 54000, Pakistan
dc.contributor.otherInstitute of Industrial Biotechnology (IIB), Government College University, Lahore 54000, Pakistan
dc.contributor.otherOffice of Research, Innovation & Commercialization, Lahore College for Women University, Lahore 54000, Pakistan
dc.contributor.otherFaculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania
dc.contributor.otherFaculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania
dc.contributor.otherFaculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania
dc.contributor.otherFaculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania
dc.date.accessioned2025-10-09T05:18:46Z
dc.date.available2025-10-09T05:18:46Z
dc.date.issued01-04-2021
dc.identifier.urihttps://www.mdpi.com/2218-273X/11/4/603
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40945
dc.description.abstractPodophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the frontline chemotherapeutic drug used against various cancers due to its superior anticancer activity. It has recently been redeveloped for the purpose of treating cytokine storm in COVID-19 patients. Podophyllotoxin and its naturally occurring congeners have low bioavailability and almost all these initially discovered compounds cause systemic toxicity and development of drug resistance. Moreover, the production of synthetic derivatives that could suffice for the clinical limitations of these naturally occurring compounds is not economically feasible. These challenges demanded continuous devotions towards improving the druggability of these drugs and continue to seek structure-optimization strategies. The discovery of renewable sources including microbial origin for podophyllotoxin is another possible approach. This review focuses on the exigency of innovation and research required in the global R&D and pharmaceutical industry for podophyllotoxin and related compounds based on recent scientific findings and market predictions.
dc.language.isoEN
dc.publisherMDPI AG
dc.subject.lccMicrobiology
dc.titlePodophyllotoxin: History, Recent Advances and Future Prospects
dc.typeArticle
dc.description.keywordsnovel biomolecules
dc.description.keywordsantitumor phytochemical
dc.description.keywordspodophyllotoxins
dc.description.keywordschemotherapy
dc.description.keywordsCOVID-19
dc.description.keywordscytokine storm
dc.description.doi10.3390/biom11040603
dc.title.journalBiomolecules
dc.identifier.e-issn2218-273X
dc.identifier.oaioai:doaj.org/journal:4b9f9c49e2da41a683fef90579955e53
dc.journal.infoVolume 11, Issue 4


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