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COVID-19 trends at the University of Tennessee: predictive insights from raw sewage SARS-CoV-2 detection and evaluation and PMMoV as an indicator for human waste

dc.contributor.authorYe Li
dc.contributor.authorKurt Ash
dc.contributor.authorKurt Ash
dc.contributor.authorIsablla Alamilla
dc.contributor.authorDominique Joyner
dc.contributor.authorDaniel Edward Williams
dc.contributor.authorPeter J. McKay
dc.contributor.authorBrianna Green
dc.contributor.authorSydney DeBlander
dc.contributor.authorCarman North
dc.contributor.authorFadime Kara-Murdoch
dc.contributor.authorFadime Kara-Murdoch
dc.contributor.authorFadime Kara-Murdoch
dc.contributor.authorCynthia Swift
dc.contributor.authorCynthia Swift
dc.contributor.authorTerry C. Hazen
dc.contributor.authorTerry C. Hazen
dc.contributor.authorTerry C. Hazen
dc.contributor.authorTerry C. Hazen
dc.contributor.authorTerry C. Hazen
dc.contributor.otherDepartment of Civil and Environmental Sciences, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherDepartment of Civil and Environmental Sciences, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States
dc.contributor.otherBattelle Memorial Institute, Columbus, OH, United States
dc.contributor.otherDepartment of Civil and Environmental Sciences, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherCenter for Environmental Biotechnology, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherBattelle Memorial Institute, Columbus, OH, United States
dc.contributor.otherDepartment of Microbiology, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherCollege of Natural Science, Michigan State University, East Lansing, MI, United States
dc.contributor.otherStudent Health Center, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherDepartment of Civil and Environmental Sciences, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherBattelle Memorial Institute, Columbus, OH, United States
dc.contributor.otherCenter for Environmental Biotechnology, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherDepartment of Civil and Environmental Sciences, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherCenter for Environmental Biotechnology, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherDepartment of Civil and Environmental Sciences, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States
dc.contributor.otherDepartment of Microbiology, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherDepartment of Earth and Planetary Sciences, University of Tennessee, Knoxville, TN, United States
dc.contributor.otherInstitute for a Secure and Sustainable Environment, University of Tennessee, Knoxville, TN, United States
dc.date.accessioned2025-10-09T05:33:37Z
dc.date.available2025-10-09T05:33:37Z
dc.date.issued01-03-2024
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fmicb.2024.1379194/full
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/41168
dc.description.abstractWastewater-based epidemiology (WBE) has become a valuable tool for monitoring the prevalence of SARS-CoV-2 on university campuses. However, concerns about effectiveness of raw sewage as a COVID-19 early warning system still exist, and it’s not clear how useful normalization by simultaneous comparison of Pepper Mild Mottle Virus (PMMoV) is in addressing variations resulting from fecal discharge dilution. This study aims to contribute insights into these aspects by conducting an academic-year field trial at the student residences on the University of Tennessee, Knoxville campus, raw sewage. This was done to investigate the correlations between SARS-CoV-2 RNA load, both with and without PMMoV normalization, and various parameters, including active COVID-19 cases, self-isolations, and their combination among all student residents. Significant positive correlations between SARS-CoV-2 RNA load a week prior, during the monitoring week, and the subsequent week with active cases. Despite these correlations, normalization by PMMoV does not enhance these associations. These findings suggest the potential utility of SARS-CoV-2 RNA load as an early warning indicator and provide valuable insights into the application and limitations of WBE for COVID-19 surveillance specifically within the context of raw sewage on university campuses.
dc.language.isoEN
dc.publisherFrontiers Media S.A.
dc.subject.lccMicrobiology
dc.titleCOVID-19 trends at the University of Tennessee: predictive insights from raw sewage SARS-CoV-2 detection and evaluation and PMMoV as an indicator for human waste
dc.typeArticle
dc.description.keywordsSARS-CoV-2
dc.description.keywordsPMMoV
dc.description.keywordsCOVID-19
dc.description.keywordsraw wastewater
dc.description.keywordssewage
dc.description.keywordsWBE
dc.description.doi10.3389/fmicb.2024.1379194
dc.title.journalFrontiers in Microbiology
dc.identifier.e-issn1664-302X
dc.identifier.oaioai:doaj.org/journal:46574d0044ca4ee7996148fa46b465fa


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