Mureş crosses over a length of 105 km, a broad tectonic corridor between mountains Şureanu, Poiana Rusca Mountains and the Apuseni Mountains in the north. Hunedoara County has significant quantities of mineral resources, mining specific activities effectively represents one of the main economic sectors. Ore processing gave rise to significant amounts of mining waste. Tailings dams and waste dumps obtained from ore processing in preparation plants are large and have led to changes in the morphology of the area. The purpose of this study is to examine the degree of pollution of the river Mures in Hunedoara county, with heavy metals due to various human activities. For monitoring and evaluation in terms of water quality of the river Mures and studying the degree and effects of pollution were collected and analyzed water samples from Mures River and tributaries from the main mining areas, such Certej. Samples were analyzed by emission spectrometry with inductively coupled plasma and the results of measurements allowed us to assess the degree of pollution of the aquatic environment and sediments . The effects of mining waste on the environment persists for a long time , even after the operation closed. Rehabilitation mining areas and those adjacent to improve the quality of life, as a prerequisite for sustainable development.