Abstract Trust is a cornerstone and enabler of human civilization, determining the very nature of how people interact with each other. The swift integration of artificial intelligence (AI) into daily life poses grand societal challenges and necessitates a reevaluation of trust. Our bibliometric literature review calls for scientists and stakeholders to cross traditional academic boundaries to address emerging and evolving societal challenges arising from AI. We propose a transdisciplinary research framework to understand and bolster trust in AI and address grand challenges in domains as diverse and urgent as misinformation, discrimination, and warfare.